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VTN
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Plasma. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
alphav-beta3 integrin-vitronectin complex; basement membrane; collagen-containing extracellular matrix; endoplasmic reticulum; extracellular region; extracellular space; Golgi lumen; intracellular membrane-bounded organelle; peptidase inhibitor complex; protein complex involved in cell-matrix adhesion; rough endoplasmic reticulum lumen
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Molecular Function:
collagen binding; extracellular matrix binding; extracellular matrix structural constituent; heparin binding; identical protein binding; integrin binding; polysaccharide binding; protein binding; scavenger receptor activity
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Biological Process:
cell adhesion; cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; endocytosis; endodermal cell differentiation; extracellular matrix organization; immune response; liver regeneration; negative regulation of blood coagulation; negative regulation of endopeptidase activity; negative regulation of fibrinolysis; oligodendrocyte differentiation; positive regulation of cell-substrate adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of wound healing; protein polymerization; regulation of cell adhesion; smooth muscle cell-matrix adhesion
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Reference #:
P04004
(UniProtKB)
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Alt. Names/Synonyms: complement S-protein; epibolin; S-protein; serum spreading factor; Serum-spreading factor; somatomedin B; Somatomedin-B; V75; Vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S-protein); Vitronectin V10 subunit; Vitronectin V65 subunit; VN; VNT; VTN; VTNC
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Gene Symbols: VTN
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Molecular weight:
54,306 Da
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Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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