VTN Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Plasma. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  alphav-beta3 integrin-vitronectin complex; basement membrane; collagen-containing extracellular matrix; endoplasmic reticulum; extracellular region; extracellular space; Golgi lumen; intracellular membrane-bounded organelle; rough endoplasmic reticulum lumen
Molecular Function:  collagen binding; extracellular matrix binding; extracellular matrix structural constituent; heparin binding; identical protein binding; integrin binding; polysaccharide binding; protein binding; scavenger receptor activity
Biological Process:  cell adhesion; cell adhesion mediated by integrin; cell migration; cell proliferation; cell-matrix adhesion; endodermal cell differentiation; extracellular matrix organization; immune response; liver regeneration; negative regulation of blood coagulation; negative regulation of endopeptidase activity; oligodendrocyte differentiation; positive regulation of cell-substrate adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of wound healing; protein polymerization; regulation of complement activation; smooth muscle cell-matrix adhesion; vesicle-mediated transport
Reference #:  P04004 (UniProtKB)
Alt. Names/Synonyms: complement S-protein; epibolin; S-protein; serum spreading factor; Serum-spreading factor; somatomedin B; Somatomedin-B; V75; Vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S-protein); Vitronectin V10 subunit; Vitronectin V65 subunit; VN; VNT; VTN; VTNC
Gene Symbols: VTN
Molecular weight: 54,306 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Select Structure to View Below

VTN

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene