SET Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Belongs to the nucleosome assembly protein (NAP) family. Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 9q34.11
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; lipid droplet; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  DNA binding; histone binding; protein binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity
Biological Process:  DNA replication; negative regulation of histone acetylation; negative regulation of neuron apoptotic process; negative regulation of phosphoprotein phosphatase activity; negative regulation of transcription, DNA-templated; nucleosome assembly; nucleosome disassembly; regulation of mRNA stability; viral process
Disease: Mental Retardation, Autosomal Dominant 58
Reference #:  Q01105 (UniProtKB)
Alt. Names/Synonyms: 2PP2A; chromatin remodelling factor; HLA-DR-associated protein II; I-2PP2A; I2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; IPP2A2; MRD58; PHAPII; Phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; Protein SET; SET; SET nuclear oncogene; SET nuclear proto-oncogene; SET translocation (myeloid leukemia-associated); TAF-I; TAF-IBETA; Template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Gene Symbols: SET
Molecular weight: 33,489 Da
Basal Isoelectric point: 4.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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