PIP4K2B iso2 Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  autophagosome; cytosol; endoplasmic reticulum membrane; nucleoplasm; plasma membrane
Molecular Function:  1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; protein binding; protein homodimerization activity
Biological Process:  cell surface receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; phospholipid metabolic process; positive regulation of autophagosome assembly; regulation of autophagy; regulation of phosphatidylinositol 3-kinase signaling
Reference #:  P78356-2 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-4-phosphate kinase; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; phosphatidylinositol-5-phosphate 4-kinase type 2 beta; PI(5)P 4-kinase type II beta; PI42B; PI5P4KB; PIP4K2B; PIP4K2B iso2; PIP4KII-beta; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PIP5P4KB; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta
Gene Symbols: PIP4K2B
Molecular weight: 32,317 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
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PIP4K2B iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene