PLCB3 iso2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  cytosol; membrane; nucleoplasm; postsynaptic cytosol; protein-containing complex
Molecular Function:  calcium ion binding; calmodulin binding; phospholipase C activity; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; lipid catabolic process; regulation of systemic arterial blood pressure; Wnt signaling pathway, calcium modulating pathway
Reference #:  Q01970-2 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3; PLCB3
Gene Symbols: PLCB3
Molecular weight: 131,205 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Phospholipase Signaling
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PLCB3 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein