| PKIA Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. Note: This description may include information from UniProtKB. |
| Protein type: Inhibitor |
| Chromosomal Location of Human Ortholog: 3|3 A1 |
| Cellular Component: cytoplasm; nucleus |
| Molecular Function: cAMP-dependent protein kinase inhibitor activity; protein binding; protein kinase A catalytic subunit binding; protein kinase inhibitor activity |
| Biological Process: negative regulation of cAMP-dependent protein kinase activity; negative regulation of catalytic activity; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; regulation of G2/M transition of mitotic cell cycle |
| Reference #: P63248 (UniProtKB) |
| Alt. Names/Synonyms: AI415001; cAMP-dependent protein kinase inhibitor alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform; IPKA; PKI-alpha; Pkia; PKIalpha; protein kinase inhibitor, alpha |
| Gene Symbols: Pkia |
| Molecular weight: 7,960 Da |
| Basal Isoelectric point: 4.42 Predict pI for various phosphorylation states |
| Select Structure to View Below |
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PKIA |
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Cross-references to other databases:
STRING
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BioGPS
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Pfam
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