PKIA Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 3|3 A1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cAMP-dependent protein kinase inhibitor activity; protein binding; protein kinase A catalytic subunit binding; protein kinase inhibitor activity
Biological Process:  negative regulation of cAMP-dependent protein kinase activity; negative regulation of catalytic activity; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; regulation of G2/M transition of mitotic cell cycle
Reference #:  P63248 (UniProtKB)
Alt. Names/Synonyms: AI415001; cAMP-dependent protein kinase inhibitor alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform; IPKA; PKI-alpha; Pkia; PKIalpha; protein kinase inhibitor, alpha
Gene Symbols: Pkia
Molecular weight: 7,960 Da
Basal Isoelectric point: 4.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene