PKIA
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. Note: This description may include information from UniProtKB.
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Protein type: Inhibitor |
Chromosomal Location of Human Ortholog: 3|3 A1 |
Cellular Component:
cytoplasm; nucleus
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Molecular Function:
cAMP-dependent protein kinase inhibitor activity; protein binding; protein kinase A catalytic subunit binding; protein kinase inhibitor activity
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Biological Process:
negative regulation of cAMP-dependent protein kinase activity; negative regulation of catalytic activity; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; regulation of G2/M transition of mitotic cell cycle
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Reference #:
P63248
(UniProtKB)
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Alt. Names/Synonyms: AI415001; cAMP-dependent protein kinase inhibitor alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform; IPKA; PKI-alpha; Pkia; PKIalpha; protein kinase inhibitor, alpha
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Gene Symbols: Pkia
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Molecular weight:
7,960 Da
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Basal Isoelectric point:
4.42
Predict pI for various phosphorylation states
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