Rb retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 15q11
Cellular Component:  chromatin; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; transcription elongation factor complex b; transcription factor complex
Molecular Function:  DNA binding; enzyme binding; identical protein binding; kinase binding; phosphoprotein binding; protein binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  apoptosis; cell cycle arrest; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cellular response to xenobiotic stimulus; chromatin organization; enucleate erythrocyte differentiation; G1/S transition of mitotic cell cycle; gut development; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of hepatocyte apoptotic process; negative regulation of mitotic cell cycle; negative regulation of protein kinase activity; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; neuron apoptosis; neuron differentiation; neuron maturation; neuron projection development; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of cohesin loading; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription from RNA polymerase II promoter; sister chromatid biorientation; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription, DNA-dependent
Reference #:  P33568 (UniProtKB)
Alt. Names/Synonyms: pp105; pRb; Rb; Rb-1; Rb1; retinoblastoma 1; Retinoblastoma 1 (including osteosarcoma); Retinoblastoma-associated protein
Gene Symbols: Rb1
Molecular weight: 105,025 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Protein Acetylation
Select Structure to View Below

Rb

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA