The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. Expressed in all tissues. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Molecular Function: actin filament binding; calcium channel regulator activity; high voltage-gated calcium channel activity; identical protein binding; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Biological Process: calcium ion import; calcium ion transmembrane transport; calcium ion transport; chemical synaptic transmission; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; neuromuscular junction development; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of calcium ion transport; positive regulation of high voltage-gated calcium channel activity; protein localization to plasma membrane; regulation of heart rate by cardiac conduction; regulation of voltage-gated calcium channel activity; visual perception