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CACNB2
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. Expressed in all tissues. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium |
| Chromosomal Location of mouse Ortholog: 2 A2|2 10.7 cM |
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Cellular Component:
L-type voltage-gated calcium channel complex; membrane; photoreceptor ribbon synapse; plasma membrane; voltage-gated calcium channel complex
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Molecular Function:
actin filament binding; calcium channel activity; calcium channel regulator activity; high voltage-gated calcium channel activity; identical protein binding; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; voltage-gated monoatomic ion channel activity
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Biological Process:
calcium ion import; calcium ion transmembrane transport; calcium ion transport; chemical synaptic transmission; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; monoatomic ion transport; neuromuscular junction development; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of calcium ion transport; positive regulation of high voltage-gated calcium channel activity; protein localization to plasma membrane; regulation of heart rate by cardiac conduction; regulation of monoatomic ion transmembrane transport; regulation of voltage-gated calcium channel activity; visual perception
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Reference #:
Q8CC27
(UniProtKB)
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Alt. Names/Synonyms: AW060387; CAB2; CACB2; Cacnb2; Cacnlb2; calcium channel beta 2 subunit; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; Cavbe; Cavbeta2; Cchb2; MGC129334; MGC129335; OTTMUSP00000012041; Voltage-dependent L-type calcium channel subunit beta-2; voltage-gated calcium channel beta2 subunit transcript variant X13
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Gene Symbols: Cacnb2
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Molecular weight:
73,149 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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