CACNB2 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. Expressed in all tissues. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 2 A2|2 10.7 cM
Cellular Component:  L-type voltage-gated calcium channel complex; membrane; photoreceptor ribbon synapse; plasma membrane; voltage-gated calcium channel complex
Molecular Function:  actin filament binding; calcium channel activity; calcium channel regulator activity; high voltage-gated calcium channel activity; identical protein binding; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels; voltage-gated ion channel activity
Biological Process:  calcium ion import; calcium ion transmembrane transport; calcium ion transport; chemical synaptic transmission; ion transport; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; neuromuscular junction development; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of calcium ion transport; positive regulation of high voltage-gated calcium channel activity; protein localization to plasma membrane; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; regulation of voltage-gated calcium channel activity; visual perception
Reference #:  Q8CC27 (UniProtKB)
Alt. Names/Synonyms: AW060387; CAB2; CACB2; Cacnb2; Cacnlb2; calcium channel beta 2 subunit; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; Cavbeta2; Cchb2; MGC129334; MGC129335; OTTMUSP00000012041; Voltage-dependent L-type calcium channel subunit beta-2
Gene Symbols: Cacnb2
Molecular weight: 73,149 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene