CACNB2 The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 10p12.33-p12.31
Cellular Component:  integral component of plasma membrane; L-type voltage-gated calcium channel complex; plasma membrane; voltage-gated calcium channel complex
Molecular Function:  actin filament binding; calcium channel activity; high voltage-gated calcium channel activity; protein binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in cardiac muscle cell action potential
Biological Process:  membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; neuromuscular junction development; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of calcium ion transport; protein localization to plasma membrane; regulation of heart rate by cardiac conduction; regulation of voltage-gated calcium channel activity; synaptic transmission; visual perception
Disease: Brugada Syndrome 4
Reference #:  Q08289 (UniProtKB)
Alt. Names/Synonyms: CAB2; CACB2; CACNB2; CACNLB2; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; CAVB2; FLJ23743; Lambert-Eaton myasthenic syndrome antigen B; myasthenic (Lambert-Eaton) syndrome antigen B; MYSB; Voltage-dependent L-type calcium channel subunit beta-2
Gene Symbols: CACNB2
Molecular weight: 73,581 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Select Structure to View Below

CACNB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein