VDR Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  caveola; cytoplasm; cytosol; dense fibrillar component; euchromatin; heterochromatin; intracellular membrane-bound organelle; nuclear heterochromatin; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; receptor complex; RNA polymerase II transcription factor complex; T-tubule
Molecular Function:  calcitriol binding; calcitriol receptor activity; DNA binding; DNA binding transcription factor activity; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; lithocholic acid binding; lithocholic acid receptor activity; metal ion binding; protein binding; retinoid X receptor binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity, direct ligand regulated sequence-specific DNA binding; transcription factor binding; vitamin D binding; zinc ion binding
Biological Process:  bile acid signaling pathway; calcium ion transport; cell differentiation; cell morphogenesis; cellular calcium ion homeostasis; intestinal absorption; lactation; multicellular organism development; negative regulation of cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; organ morphogenesis; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vitamin D 24-hydroxylase activity; regulation of calcium ion transport; regulation of transcription, DNA-templated; skeletal system development; transcription, DNA-dependent
Reference #:  P48281 (UniProtKB)
Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; Nuclear receptor subfamily 1 group I member 1; VDR; vitamin D receptor; Vitamin D3 receptor
Gene Symbols: Vdr
Molecular weight: 47,834 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA