VDR Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  cytoplasm; cytosol; dense fibrillar component; euchromatin; heterochromatin; intracellular membrane-bounded organelle; nuclear heterochromatin; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; receptor complex; RNA polymerase II transcription factor complex; T-tubule
Molecular Function:  calcitriol binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; lithocholic acid binding; lithocholic acid receptor activity; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; retinoid X receptor binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; vitamin D binding; zinc ion binding
Biological Process:  animal organ morphogenesis; apoptotic signaling pathway; bile acid signaling pathway; calcium ion transport; cell differentiation; cell morphogenesis; cellular calcium ion homeostasis; intestinal absorption; lactation; mammary gland branching involved in pregnancy; multicellular organism development; negative regulation of cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of vitamin D 24-hydroxylase activity; regulation of calcidiol 1-monooxygenase activity; regulation of calcium ion transport; regulation of transcription, DNA-templated; skeletal system development; vitamin D receptor signaling pathway
Reference #:  P48281 (UniProtKB)
Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; Nuclear receptor subfamily 1 group I member 1; VDR; vitamin D receptor; Vitamin D3 receptor
Gene Symbols: Vdr
Molecular weight: 47,834 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA