VDR Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.11

Cellular Component: cytoplasm; nucleoplasm; nucleus; receptor complex; RNA polymerase II transcription factor complex

Molecular Function: calcitriol binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; lithocholic acid binding; lithocholic acid receptor activity; nuclear receptor activity; protein binding; retinoid X receptor binding; signaling receptor activity; steroid hormone receptor activity; zinc ion binding

Biological Process: bile acid signaling pathway; calcium ion transport; cell morphogenesis; cellular calcium ion homeostasis; decidualization; intestinal absorption; lactation; mammary gland branching involved in pregnancy; negative regulation of cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of vitamin D 24-hydroxylase activity; regulation of calcidiol 1-monooxygenase activity; signal transduction; skeletal system development; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter; vitamin D metabolic process; vitamin D receptor signaling pathway

Disease: Vitamin D-dependent Rickets, Type 2a

Reference #: P11473 (UniProtKB)

Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; NR1I1; nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; Vitamin D3 receptor

Gene Symbols: VDR

Molecular weight: 48,289 Da

Basal Isoelectric point: 6.08 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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VDR

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