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ChREBP
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
carbohydrate response element binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding
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Biological Process:
anatomical structure morphogenesis; energy homeostasis; fatty acid homeostasis; glucose homeostasis; glucose mediated signaling pathway; lipid biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of oxidative phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of fatty acid biosynthetic process; positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; triglyceride homeostasis
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Disease: Williams-beuren Syndrome
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Reference #:
Q9NP71
(UniProtKB)
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Alt. Names/Synonyms: BHLHD14; carbohydrate response element binding protein; Carbohydrate-responsive element-binding protein; CHREBP; Class D basic helix-loop-helix protein 14; MIO; MLX; MLX interacting protein like; MLX interacting protein-like; MLX interactor; MLX-interacting protein-like; MLXIPL; MLXPL; MONDOB; WBS14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2; Williams-Beuren syndrome chromosome region 14 protein 3; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
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Gene Symbols: MLXIPL
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Molecular weight:
93,073 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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