ChREBP Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. Binds DNA as a heterodimer with TCFL4/MLX. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  carbohydrate response element binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; transcription factor binding
Biological Process:  anatomical structure morphogenesis; energy homeostasis; fatty acid homeostasis; glucose homeostasis; glucose mediated signaling pathway; intracellular signal transduction; negative regulation of cell cycle arrest; negative regulation of oxidative phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of cell proliferation; positive regulation of fatty acid biosynthetic process; positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; triglyceride homeostasis
Disease: Williams-beuren Syndrome
Reference #:  Q9NP71 (UniProtKB)
Alt. Names/Synonyms: BHLHD14; carbohydrate response element binding protein; Carbohydrate-responsive element-binding protein; CHREBP; Class D basic helix-loop-helix protein 14; MIO; MLX interacting protein-like; MLX interactor; MLX-interacting protein-like; MLXIPL; MONDOB; WBS14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
Gene Symbols: MLXIPL
Molecular weight: 93,073 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein