SPTBN1 Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. Isoform 2 is present in brain, lung and kidney (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 11 A3.3|11 17.44 cM
Cellular Component:  axolemma; cell junction; cell projection; cortical actin cytoskeleton; cortical cytoskeleton; cuticular plate; cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; M band; membrane; nucleolus; nucleus; plasma membrane; postsynapse; postsynaptic density; protein-containing complex; spectrin
Molecular Function:  actin binding; actin filament binding; ankyrin binding; calmodulin binding; GTPase binding; phospholipid binding; protein binding; protein-containing complex binding; structural constituent of cytoskeleton
Biological Process:  actin cytoskeleton organization; actin filament capping; central nervous system development; central nervous system formation; common-partner SMAD protein phosphorylation; Golgi to plasma membrane protein transport; membrane assembly; mitotic cytokinesis; plasma membrane organization; positive regulation of interleukin-2 production; positive regulation of protein localization to plasma membrane; protein localization to plasma membrane; regulation of protein localization to plasma membrane; regulation of SMAD protein signal transduction
Reference #:  Q62261 (UniProtKB)
Alt. Names/Synonyms: 9930031C03Rik; AL033301; beta fodrin; Beta-II spectrin; beta-spectrin 2, non-erythrocytic; brain spectrin; Elf; elf1; elf3; Embryonic liver fodrin; Fodrin beta chain; KIAA4049; mKIAA4049; non-erythrocytic; OTTMUSP00000005519; OTTMUSP00000005520; spectrin beta 2; Spectrin beta chain, brain 1; Spectrin beta chain, non-erythrocytic 1; spectrin beta, non-erythrocytic 1; spectrin G; Spectrin, non-erythroid beta chain 1; Spn; Spnb-2; Spnb2; Sptb2; Sptbn1
Gene Symbols: Sptbn1
Molecular weight: 274,223 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene