SHB Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 9p13.1
Cellular Component:  cytoplasmic ribonucleoprotein granule; cytosol; nucleoplasm; plasma membrane
Molecular Function:  phosphotyrosine residue binding; protein binding; signaling receptor complex adaptor activity
Biological Process:  angiogenesis; apoptotic process; B cell proliferation; hematopoietic stem cell proliferation; negative regulation of oocyte maturation; negative regulation of protein kinase activity; positive regulation of mitotic cell cycle; positive regulation of T-helper cell differentiation; signal transduction; T cell receptor signaling pathway
Reference #:  Q15464 (UniProtKB)
Alt. Names/Synonyms: bA3J10.2; RP11-3J10.8; SH2 domain containing adaptor protein B; SH2 domain-containing adapter protein B; SHB; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); Src homology 2 domain containing adaptor protein B
Gene Symbols: SHB
Molecular weight: 55,042 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein