Plectin-1 Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Belongs to the plakin or cytolinker family. Widely expressed with highest levels in muscle, heart, placenta and spinal cord. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  apical plasma membrane; basal plasma membrane; brush border; contractile fiber; costamere; cytoplasm; cytoskeleton; cytosol; focal adhesion; hemidesmosome; intermediate filament cytoskeleton; membrane; perinuclear region of cytoplasm; sarcolemma; sarcoplasm
Molecular Function:  actin binding; ankyrin binding; cytoskeletal protein binding; protein N-terminus binding; structural constituent of cytoskeleton; structural constituent of muscle; structural molecule activity
Biological Process:  cytoskeleton organization; epithelial cell differentiation; female pregnancy; hemidesmosome assembly; intermediate filament cytoskeleton organization; response to nutrient; wound healing
Reference #:  P30427 (UniProtKB)
Alt. Names/Synonyms: PCN; Plec; Plec1; Plectin; plectin 1; Plectin-1; PLTN
Gene Symbols: Plec1
Molecular weight: 533,540 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene