C1R C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.41; Protease
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  extracellular region; extracellular space
Molecular Function:  calcium ion binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  complement activation; complement activation, classical pathway; immune response; innate immune response; regulation of complement activation; zymogen activation
Disease: Ehlers-danlos Syndrome, Periodontal Type, 1
Reference #:  P00736 (UniProtKB)
Alt. Names/Synonyms: C1R; Complement C1r subcomponent; Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain; Complement component 1 subcomponent r; complement component 1, r subcomponent
Gene Symbols: C1R
Molecular weight: 80,119 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
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C1R

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene