TSC2 iso2 In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex
Molecular Function:  GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding
Biological Process:  anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport; viral process
Reference #:  P49815-2 (UniProtKB)
Alt. Names/Synonyms: TSC2; TSC2 iso2; TSC4; Tuberin; Tuberous sclerosis 2 protein
Gene Symbols: TSC2
Molecular weight: 195,847 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
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TSC2 iso2

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA