RARA Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression. Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells. In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in monocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11 D|11 62.76 cM
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; dendrite; neuron projection; neuronal cell body; nuclear chromatin; nucleus; perinuclear region of cytoplasm; RNA polymerase II transcription factor complex
Molecular Function:  alpha-actinin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; drug binding; enzyme binding; histone deacetylase binding; metal ion binding; mRNA 5'-UTR binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; phosphatidylinositol 3-kinase regulator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; retinoic acid binding; retinoic acid-responsive element binding; RNA polymerase II regulatory region DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; signaling receptor binding; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; translation repressor activity, mRNA regulatory element binding; zinc ion binding
Biological Process:  apoptotic cell clearance; bone development; bone morphogenesis; cell differentiation; cellular response to estrogen stimulus; cellular response to lipopolysaccharide; cellular response to retinoic acid; chondroblast differentiation; embryonic camera-type eye development; epithelium development; face development; germ cell development; gland development; glandular epithelial cell development; growth plate cartilage development; hormone-mediated signaling pathway; limb development; liver development; male gonad development; multicellular organism development; multicellular organism growth; negative regulation of apoptotic process; negative regulation of cartilage development; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of translational initiation; negative regulation of tumor necrosis factor production; neural tube closure; outflow tract septum morphogenesis; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of apoptotic process; regulation of granulocyte differentiation; regulation of myelination; regulation of synaptic plasticity; regulation of transcription, DNA-templated; response to ethanol; response to lipid; response to retinoic acid; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; signal transduction; spermatogenesis; trachea cartilage development; ureteric bud development; ventricular cardiac muscle cell differentiation
Reference #:  P11416 (UniProtKB)
Alt. Names/Synonyms: Nr1b1; Nuclear receptor subfamily 1 group B member 1; OTTMUSP00000006834; OTTMUSP00000006835; OTTMUSP00000006836; RAR; RAR alpha 1; RAR-alpha; Rara; RARalpha1; Retinoic acid receptor alpha; retinoic acid receptor, alpha
Gene Symbols: Rara
Molecular weight: 50,735 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RARA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA