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SPTB1
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Belongs to the spectrin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 12 C3|12 33.73 cM |
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Cellular Component:
cell junction; cell projection; cell surface; cortical actin cytoskeleton; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; membrane; plasma membrane; postsynapse; protein-containing complex; spectrin; spectrin-associated cytoskeleton
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Molecular Function:
actin binding; actin filament binding; ankyrin binding; protein binding; structural constituent of cytoskeleton
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Biological Process:
actin cytoskeleton organization; actin filament capping; hemopoiesis; modification of postsynaptic actin cytoskeleton; plasma membrane organization; porphyrin-containing compound biosynthetic process
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Reference #:
P15508
(UniProtKB)
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Alt. Names/Synonyms: AI842465; Beta-I spectrin; beta-spectrin 1; brain erythroid spectrin (235E); D330027P03Rik; Gm1301; ja; jaundiced; KIAA4219; mKIAA4219; spectrin beta 1; Spectrin beta chain, erythrocyte; Spectrin beta chain, erythrocytic; spectrin beta, erythrocytic; spectrin R; Spn; Spnb-1; Spnb1; Sptb; Sptb1
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Gene Symbols: Sptb
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Molecular weight:
245,250 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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