Tel Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. Belongs to the ETS family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component:  cytosol; nucleolus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein domain specific binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  hematopoietic stem cell proliferation; mesenchymal cell apoptotic process; negative regulation of transcription by RNA polymerase II; neurogenesis; positive regulation of transcription by RNA polymerase II; vitellogenesis
Disease: Leukemia, Acute Myeloid; Thrombocytopenia 5
Reference #:  P41212 (UniProtKB)
Alt. Names/Synonyms: ETS translocation variant 6; ets variant 6; ets variant gene 6 (TEL oncogene); ETS variant transcription factor 6; ETS-related protein Tel1; ETV6; ETV6-NTRK3 fusion partner; TEL; TEL/ABL; TEL1; TEL1 oncogene; THC5; Transcription factor ETV6
Gene Symbols: ETV6
Molecular weight: 53,000 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB