GLP1R G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. Belongs to the G-protein coupled receptor 2 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 6p21.2
Cellular Component:  membrane; plasma membrane
Molecular Function:  glucagon receptor activity; glucagon-like peptide 1 receptor activity; peptide hormone binding; protein binding; transmembrane signaling receptor activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP-mediated signaling; cell surface receptor signaling pathway; cellular response to glucagon stimulus; hormone secretion; learning or memory; negative regulation of blood pressure; positive regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; post-translational protein targeting to membrane, translocation; regulation of heart contraction; response to psychosocial stress
Reference #:  P43220 (UniProtKB)
Alt. Names/Synonyms: GLP-1; GLP-1 receptor; GLP-1-R; GLP-1R; GLP1 receptor; GLP1R; glucagon like peptide 1 receptor; Glucagon-like peptide 1 receptor; MGC138331; seven transmembrane helix receptor
Gene Symbols: GLP1R
Molecular weight: 53,026 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein