FLNA Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. Belongs to the filamin family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: X A7.3|X 37.89 cM
Cellular Component:  actin cytoskeleton; actin filament; actin filament bundle; apical dendrite; brush border; cell cortex; cell-cell junction; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; dendritic shaft; glutamatergic synapse; growth cone; Myb complex; neuronal cell body; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynapse; trans-Golgi network; Z disc
Molecular Function:  actin binding; actin filament binding; Fc-gamma receptor I complex binding; G protein-coupled receptor binding; GTPase binding; ion channel binding; kinase binding; mu-type opioid receptor binding; potassium channel regulator activity; protein binding; protein homodimerization activity; protein kinase C binding; protein-containing complex binding; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; SMAD binding; small GTPase binding; transcription factor binding
Biological Process:  actin crosslink formation; actin cytoskeleton organization; actin cytoskeleton reorganization; adenylate cyclase-inhibiting dopamine receptor signaling pathway; angiogenesis; blood vessel remodeling; cell projection organization; cell-cell junction organization; cilium assembly; cytoplasmic sequestering of protein; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; establishment of Sertoli cell barrier; formation of radial glial scaffolds; heart morphogenesis; mitotic spindle assembly; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of DNA-binding transcription factor activity; negative regulation of neuron projection development; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase I; positive regulation of actin filament bundle assembly; positive regulation of integrin-mediated signaling pathway; positive regulation of neural precursor cell proliferation; positive regulation of neuron migration; positive regulation of potassium ion transmembrane transport; positive regulation of protein import into nucleus; positive regulation of substrate adhesion-dependent cell spreading; protein localization to bicellular tight junction; protein localization to cell surface; protein localization to plasma membrane; protein stabilization; receptor clustering; regulation of actin filament bundle assembly; regulation of cell migration; regulation of membrane repolarization during atrial cardiac muscle cell action potential; regulation of membrane repolarization during cardiac muscle cell action potential; semaphorin-plexin signaling pathway; synapse organization; wound healing, spreading of cells
Reference #:  Q8BTM8 (UniProtKB)
Alt. Names/Synonyms: ABP-2; ABP-280; Actin-binding protein 280; Alpha-filamin; dilated pupils 2; Dilp2; Endothelial actin-binding protein; F730004A14Rik; fila; filamin A; filamin, alpha; Filamin-1; Filamin-A; Fln; FLN-A; Fln1; Flna; GENA 379; Non-muscle filamin
Gene Symbols: Flna
Molecular weight: 281,222 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA