GluR6 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. Expression is higher in cerebellum than in cerebral cortex. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 20q13
Cellular Component:  axon; dendrite; dendrite cytoplasm; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; ionotropic glutamate receptor complex; kainate selective glutamate receptor complex; membrane; mossy fiber rosette; neuronal cell body; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; synapse; terminal bouton
Molecular Function:  extracellularly glutamate-gated ion channel activity; glutamate receptor activity; identical protein binding; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; PDZ domain binding; protein binding; scaffold protein binding; SNARE binding; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding
Biological Process:  behavioral fear response; chemical synaptic transmission; detection of cold stimulus involved in thermoception; excitatory postsynaptic potential; inhibitory postsynaptic potential; intracellular calcium ion homeostasis; intracellular protein transport; ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; modulation of excitatory postsynaptic potential; monoatomic ion transmembrane transport; negative regulation of neuron apoptotic process; negative regulation of synaptic transmission, glutamatergic; neuron apoptotic process; neuronal action potential; positive regulation of neuron apoptotic process; positive regulation of synaptic transmission; presynaptic modulation of chemical synaptic transmission; receptor clustering; regulation of JNK cascade; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of presynaptic membrane potential; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic
Reference #:  P42260 (UniProtKB)
Alt. Names/Synonyms: GluR-6; GluR6; Glutamate receptor 6; Glutamate receptor ionotropic, kainate 2; Glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; Grik2
Gene Symbols: Grik2
Molecular weight: 102,470 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene