MFNG Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Belongs to the glycosyltransferase 31 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  extracellular space; integral component of Golgi membrane
Molecular Function:  metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
Biological Process:  blastocyst formation; marginal zone B cell differentiation; pattern specification process; positive regulation of Notch signaling pathway; positive regulation of protein binding; protein O-linked fucosylation; regulation of Notch signaling pathway
Reference #:  O00587 (UniProtKB)
Alt. Names/Synonyms: Beta-1,3-N-acetylglucosaminyltransferase manic fringe; manic fringe; MFNG; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Symbols: MFNG
Molecular weight: 36,202 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
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Protein Structure Not Found.

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