G-alpha i2 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  cell body; centrosome; cytoplasm; cytosol; dendrite; membrane raft; midbody; nucleoplasm; plasma membrane
Molecular Function:  GTP binding; metal ion binding; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cell cycle; cell division; cell proliferation; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of apoptotic signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of protein tyrosine phosphatase activity; negative regulation of synaptic transmission; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin receptor signaling pathway; positive regulation of NAD(P)H oxidase activity; positive regulation of neural precursor cell proliferation; positive regulation of renal sodium excretion; positive regulation of superoxide anion generation; positive regulation of urine volume; positive regulation of vascular smooth muscle cell proliferation; protein folding; regulation of calcium ion transport; response to nutrient; signal transduction
Disease: Ventricular Tachycardia, Familial
Reference #:  P04899 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; G protein subunit alpha i2; G-alpha i2; GIP; GNAI2; GNAI2B; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; H_LUCA15.1; H_LUCA16.1
Gene Symbols: GNAI2
Molecular weight: 40,451 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
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G-alpha i2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene