G-alpha i2 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of rat Ortholog: 8q32
Cellular Component:  cell body; cellular anatomical entity; centrosome; cytoplasm; cytosol; dendrite; exocytic vesicle; heterotrimeric G-protein complex; midbody; neuronal dense core vesicle; nucleoplasm; plasma membrane; synapse
Molecular Function:  G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; metal ion binding; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell division; cell population proliferation; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled adenosine receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of apoptotic signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of protein tyrosine phosphatase activity; negative regulation of synaptic transmission; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin receptor signaling pathway; positive regulation of NAD(P)H oxidase activity; positive regulation of neural precursor cell proliferation; positive regulation of superoxide anion generation; positive regulation of urine volume; positive regulation of vascular associated smooth muscle cell proliferation; regulation of calcium ion transport; regulation of heart contraction
Reference #:  P04897 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G-alpha i2; Galphai2; Gnai-2; Gnai2; GTP-binding protein (G-alpha-i2); guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit
Gene Symbols: Gnai2
Molecular weight: 40,499 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Select Structure to View Below

G-alpha i2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene