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DHDPSL
Catalyzes the final step in the metabolic pathway of hydroxyproline. Belongs to the DapA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.1.3.16; Lyase; Mitochondrial |
| Chromosomal Location of human Ortholog: 10q24.2 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
4-hydroxy-2-oxoglutarate aldolase activity; protein binding; protein homodimerization activity
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Biological Process:
4-hydroxyproline catabolic process; glyoxylate catabolic process; glyoxylate metabolic process; oxalate metabolic process; pyruvate biosynthetic process
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Disease: Hyperoxaluria, Primary, Type Iii
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Reference #:
Q86XE5
(UniProtKB)
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Alt. Names/Synonyms: 4-hydroxy-2-oxoglutarate aldolase 1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; C10orf65; DAPAL; DHDPS-like protein; DHDPS2; DHDPSL; Dihydrodipicolinate synthase-like; Dihydrodipicolinate synthase-like, mitochondrial; dihydrodipicolinate synthetase homolog 2; FLJ37472; HOGA1; HP3; N-acetylneuraminate pyruvate lyase 2 (putative); NPL2; Probable 2-keto-4-hydroxyglutarate aldolase; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Probable KHG-aldolase; Protein 569272
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Gene Symbols: HOGA1
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Molecular weight:
35,249 Da
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Basal Isoelectric point:
8.13
Predict pI for various phosphorylation states
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