DHDPSL Catalyzes the final step in the metabolic pathway of hydroxyproline. Belongs to the DapA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lyase; Mitochondrial
Chromosomal Location of human Ortholog: 10q24.2
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  4-hydroxy-2-oxoglutarate aldolase activity; protein binding; protein homodimerization activity
Biological Process:  4-hydroxyproline catabolic process; glyoxylate catabolic process; glyoxylate metabolic process; oxalate metabolic process; pyruvate biosynthetic process
Disease: Hyperoxaluria, Primary, Type Iii
Reference #:  Q86XE5 (UniProtKB)
Alt. Names/Synonyms: 4-hydroxy-2-oxoglutarate aldolase 1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; C10orf65; DAPAL; DHDPS-like protein; DHDPS2; DHDPSL; Dihydrodipicolinate synthase-like; Dihydrodipicolinate synthase-like, mitochondrial; dihydrodipicolinate synthetase homolog 2; FLJ37472; HOGA1; HP3; N-acetylneuraminate pyruvate lyase 2 (putative); NPL2; Probable 2-keto-4-hydroxyglutarate aldolase; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Probable KHG-aldolase; Protein 569272
Gene Symbols: HOGA1
Molecular weight: 35,249 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene