AQP7 Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney. Belongs to the MIP/aquaporin (TC 1.A.8) family. Detected in the sperm head (at protein level) (PubMed:28042826). Detected in white adipose tissue (PubMed:9405233). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  cell-cell junction; cytoplasm; integral component of plasma membrane; plasma membrane
Molecular Function:  glycerol channel activity; water channel activity
Biological Process:  glycerol transport; urea transmembrane transport; water transport
Disease: Glycerol Quantitative Trait Locus
Reference #:  O14520 (UniProtKB)
Alt. Names/Synonyms: AQP-7; AQP7; AQP7L; AQP9; AQPap; Aquaglyceroporin-7; aquaporin 7; Aquaporin adipose; Aquaporin-7; Aquaporin-7-like; GLYCQTL; MGC149555; MGC149556
Gene Symbols: AQP7
Molecular weight: 37,232 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene