MAGT1 Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. May be involved in Mg(2+) transport in epithelial cells. Belongs to the OST3/OST6 family. Ubiquitous. Expressed at very low levels in brain, lung and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xq21.1
Cellular Component:  azurophil granule membrane; endoplasmic reticulum; integral component of plasma membrane; oligosaccharyltransferase complex; plasma membrane
Molecular Function:  magnesium ion transmembrane transporter activity
Biological Process:  cognition; magnesium ion transmembrane transport; magnesium ion transport; neutrophil degranulation; protein N-linked glycosylation; protein N-linked glycosylation via asparagine; transmembrane transport
Disease: Congenital Disorder Of Glycosylation, Type Icc; Immunodeficiency, X-linked, With Magnesium Defect, Epstein-barr Virus Infection, And Neoplasia
Reference #:  Q9H0U3 (UniProtKB)
Alt. Names/Synonyms: bA217H1.1; CDG1CC; DKFZp564K142; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; FLJ14726; IAG2; IAP; Implantation-associated protein; magnesium transporter 1; Magnesium transporter protein 1; MAGT1; MGC64926; MRX95; Oligosaccharyl transferase subunit MAGT1; oligosaccharyltransferase 3 homolog B; OST3B; PRO0756; SLC58A1; XMEN
Gene Symbols: MAGT1
Molecular weight: 38,037 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Select Structure to View Below

MAGT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene