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LHX6
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 9q33.2 |
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Cellular Component:
chromatin; nucleus
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
cell maturation; cerebral cortex GABAergic interneuron migration; cerebral cortex radially oriented cell migration; cerebral cortex tangential migration; forebrain neuron development; neuron differentiation; regulation of transcription by RNA polymerase II
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Reference #:
Q9UPM6
(UniProtKB)
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Alt. Names/Synonyms: LHX6; LHX6.1; LIM homeobox 6; LIM homeobox protein 6; LIM homeodomain protein 6.1; LIM/homeobox protein Lhx6; LIM/homeobox protein Lhx6.1; MGC119542; MGC119544; MGC119545
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Gene Symbols: LHX6
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Molecular weight:
40,045 Da
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Basal Isoelectric point:
8.77
Predict pI for various phosphorylation states
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