EGR2 Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Belongs to the EGR C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; EC 6.3.2.-; SUMO conjugating system; SUMO ligase
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding; metal ion binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; SUMO ligase activity; transcription regulatory region DNA binding; ubiquitin protein ligase binding
Biological Process:  brain development; brain segmentation; cellular response to organic substance; facial nerve structural organization; fat cell differentiation; learning or memory; motor neuron axon guidance; myelination; peripheral nervous system development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein export from nucleus; protein sumoylation; regulation of neuronal synaptic plasticity; regulation of ossification; response to insulin; rhombomere 3 formation; rhombomere 5 formation; rhythmic behavior; Schwann cell differentiation; skeletal muscle cell differentiation; transcription by RNA polymerase II
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1d; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Reference #:  P11161 (UniProtKB)
Alt. Names/Synonyms: AT591; CHN1; CMT1D; CMT4E; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response 2; Early growth response protein 2; EGR-2; EGR2; FLJ14547; Krox-20 homolog, Drosophila; KROX-20, Drosophila, homolog (early growth response-2); KROX20; Zinc finger protein Krox-20
Gene Symbols: EGR2
Molecular weight: 50,302 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene