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PIGM
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Belongs to the PIGM family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.-; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase |
| Chromosomal Location of human Ortholog: 1q23.2 |
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Cellular Component:
endoplasmic reticulum membrane; glycosylphosphatidylinositol-mannosyltransferase I complex
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Molecular Function:
alpha-1,4-mannosyltransferase activity; glycolipid mannosyltransferase activity; mannosyltransferase activity
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Biological Process:
GPI anchor biosynthetic process
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Disease: Glycosylphosphatidylinositol Deficiency
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Reference #:
Q9H3S5
(UniProtKB)
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Alt. Names/Synonyms: dol-P-Man dependent GPI mannosyltransferase; DPM:GlcN-(acyl-)PI mannosyltransferase; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; MGC29896; phosphatidylinositol glycan anchor biosynthesis class M; phosphatidylinositol glycan anchor biosynthesis, class M; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M; PIG-M mannosyltransferase; PIGM
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Gene Symbols: PIGM
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Molecular weight:
49,460 Da
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Basal Isoelectric point:
9.26
Predict pI for various phosphorylation states
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