SHIK May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); SgK495 family
Chromosomal Location of mouse Ortholog: 4|4 D2.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  glycogen metabolic process; lung alveolus development; lung development; lung morphogenesis; multicellular organism growth; negative regulation of apoptotic process; phosphorylation; protein phosphorylation; regulation of gene expression; regulation of MAPK cascade; respiratory system process
Reference #:  Q7TNL3 (UniProtKB)
Alt. Names/Synonyms: 2310004N11Rik; AI428792; Lyk4; ortholog of Ser/Thr-like protein kinase Lyk4; serine/threonine kinase 40; Serine/threonine-protein kinase 40; Serine/threonine-protein kinase lyk4; SHIK; Stk40
Gene Symbols: Stk40
Molecular weight: 48,932 Da
Basal Isoelectric point: 7.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene