GHF-1
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes. Belongs to the POU transcription factor family. Class-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of rat Ortholog: 11p12 |
Cellular Component:
cytosol; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; lncRNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
adenohypophysis development; B cell differentiation; cell fate specification; cell population proliferation; determination of adult lifespan; inositol trisphosphate biosynthetic process; negative regulation of transcription by RNA polymerase II; pituitary gland development; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription by RNA polymerase II; somatotropin secreting cell development; somatotropin secreting cell differentiation
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Reference #:
P10037
(UniProtKB)
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Alt. Names/Synonyms: GHF-1; GHF1; GHF1A; Growth hormone factor 1; homeodomain protein for Growth Hormone (GH); PIT-1; Pit1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); Pituitary-specific positive transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; Pou1f1
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Gene Symbols: Pou1f1
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Molecular weight:
32,903 Da
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Basal Isoelectric point:
8.42
Predict pI for various phosphorylation states
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