GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes. Belongs to the POU transcription factor family. Class-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11p12
Cellular Component:  nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  adenohypophysis development; B cell differentiation; cell fate specification; determination of adult lifespan; negative regulation of transcription by RNA polymerase II; pituitary gland development; positive regulation of cell proliferation; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of multicellular organism growth; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription, DNA-templated; somatotropin secreting cell development; somatotropin secreting cell differentiation
Reference #:  P10037 (UniProtKB)
Alt. Names/Synonyms: GHF-1; GHF1; GHF1A; Growth hormone factor 1; homeodomain protein for Growth Hormone (GH); PIT-1; Pit1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); Pituitary-specific positive transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; Pou1f1
Gene Symbols: Pou1f1
Molecular weight: 32,903 Da
Basal Isoelectric point: 8.42  Predict pI for various phosphorylation states
Select Structure to View Below

GHF-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene