RANBP2 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Belongs to the RanBP2 E3 ligase family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO conjugating system
Chromosomal Location of Human Ortholog: 10 B4|10 29.34 cM
Cellular Component:  cytoplasm; membrane; mitochondrion; nuclear pore; nucleus
Molecular Function:  metal ion binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; Ran GTPase binding; RNA binding; SUMO transferase activity; transferase activity
Biological Process:  intracellular transport; mRNA transport; NLS-bearing protein import into nucleus; positive regulation of glucokinase activity; protein folding; protein peptidyl-prolyl isomerization; protein transport; regulation of gluconeogenesis
Reference #:  Q9ERU9 (UniProtKB)
Alt. Names/Synonyms: A430087B05Rik; AI256741; E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; NUP358; RAN binding protein 2; Ran-binding protein 2; RanBP2; RBP2
Gene Symbols: Ranbp2
Molecular weight: 341,121 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

RANBP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene