CDC14B Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, dual-specificity
Chromosomal Location of human Ortholog: 9q22.32-q22.33
Cellular Component:  centrosome; cytoplasm; mitotic spindle; nucleolus; nucleoplasm; nucleus; spindle pole
Molecular Function:  myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  cilium assembly; DNA repair; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint signaling; positive regulation of cytokinesis; positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; regulation of exit from mitosis
Reference #:  O60729 (UniProtKB)
Alt. Names/Synonyms: CC14B; CDC14 cell division cycle 14 homolog B; CDC14 cell division cycle 14 homolog B (S. cerevisiae); CDC14B; Cdc14B1; Cdc14B2; CDC14B3; cell division cycle 14B; Dual specificity protein phosphatase CDC14B; hCDC14B
Gene Symbols: CDC14B
Molecular weight: 56,802 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
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CDC14B

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein