CDC14B
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, dual-specificity |
Chromosomal Location of human Ortholog: 9q22.32-q22.33 |
Cellular Component:
centrosome; cytoplasm; mitotic spindle; nucleolus; nucleoplasm; nucleus; spindle pole
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Molecular Function:
myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
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Biological Process:
cilium assembly; DNA repair; microtubule cytoskeleton organization; mitotic G2 DNA damage checkpoint signaling; positive regulation of cytokinesis; positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; regulation of exit from mitosis
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Reference #:
O60729
(UniProtKB)
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Alt. Names/Synonyms: CC14B; CDC14 cell division cycle 14 homolog B; CDC14 cell division cycle 14 homolog B (S. cerevisiae); CDC14B; Cdc14B1; Cdc14B2; CDC14B3; cell division cycle 14B; Dual specificity protein phosphatase CDC14B; hCDC14B
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Gene Symbols: CDC14B
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Molecular weight:
56,802 Da
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Basal Isoelectric point:
9.19
Predict pI for various phosphorylation states
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