TACSTD2 May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 6|6 C1
Cellular Component:  basal plasma membrane; bicellular tight junction; extracellular space; integral component of membrane; lateral plasma membrane; membrane; nucleus; plasma membrane
Molecular Function:  cadherin binding involved in cell-cell adhesion
Biological Process:  negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of cell motility; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; negative regulation of stress fiber assembly; negative regulation of substrate adhesion-dependent cell spreading; positive regulation of stem cell differentiation; regulation of epithelial cell proliferation; ureteric bud morphogenesis
Reference #:  Q8BGV3 (UniProtKB)
Alt. Names/Synonyms: C80403; Cell surface glycoprotein Trop-2; EGP-1; GA733-1; Ly97; lymphocyte antigen 97; MGC141612; MGC141613; TACD2; Tacstd2; Trop2; Tumor-associated calcium signal transducer 2; tunor-associated calcium signal transducer 2
Gene Symbols: Tacstd2
Molecular weight: 35,574 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene