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CGB
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Belongs to the glycoprotein hormones subunit beta family. High expression in the placenta throughout pregnancy. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 19q13.33 |
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Cellular Component:
extracellular region
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Biological Process:
apoptotic process; cell-cell signaling; female gamete generation; peptide hormone processing; regulation of signaling receptor activity; regulation of transcription by RNA polymerase II; signal transduction
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Reference #:
P0DN86
(UniProtKB)
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Alt. Names/Synonyms: CG-beta; CGB; CGB3; CGB5; CGB7; CGB8; CGHB; Choriogonadotropin subunit beta; Choriogonadotropin subunit beta 3; Chorionic gonadotrophin chain beta; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin beta subunit; chorionic gonadotropin beta subunit 3; Chorionic gonadotropin chain beta; chorionic gonadotropin subunit beta 3; chorionic gonadotropin, beta polypeptide; hCGB
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Gene Symbols: CGB3
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Molecular weight:
17,739 Da
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Basal Isoelectric point:
8.49
Predict pI for various phosphorylation states
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