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MYH9
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of rat Ortholog: 7q34 |
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Cellular Component:
actin cytoskeleton; actin filament; actomyosin; actomyosin contractile ring; adherens junction; apical plasma membrane; brush border; cell cortex; cell leading edge; cleavage furrow; cortical cytoskeleton; cortical granule; cytoplasm; cytoplasmic side of plasma membrane; cytosol; endosome; exocytic vesicle; focal adhesion; immunological synapse; lamellipodium; lateral plasma membrane; myosin complex; myosin filament; myosin II complex; myosin II filament; neuromuscular junction; nuclear body; nucleus; phagocytic vesicle; plasma membrane; protein-containing complex; ruffle; spindle; stress fiber; uropod
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Molecular Function:
actin binding; actin filament binding; ADP binding; ATP binding; calmodulin binding; cytoskeletal motor activity; follicle-stimulating hormone receptor binding; G-protein alpha-subunit binding; identical protein binding; integrin binding; microfilament motor activity; P-type sodium:potassium-exchanging transporter activity; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein-membrane adaptor activity; scaffold protein binding
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Biological Process:
actin cytoskeleton organization; actin filament bundle assembly; actin filament bundle distribution; actin filament capping; actin filament polymerization; actin filament-based movement; actomyosin structure organization; angiogenesis; blood vessel endothelial cell migration; cell adhesion; cell morphogenesis involved in differentiation; cell-cell adhesion; cellular response to mechanical stimulus; cellular response to platelet-derived growth factor stimulus; cortical granule exocytosis; cytokinetic process; establishment of meiotic spindle localization; establishment of T cell polarity; establishment or maintenance of transmembrane electrochemical gradient; follicle-stimulating hormone signaling pathway; in utero embryonic development; lysosome localization; meiotic spindle organization; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; negative regulation of actin filament severing; negative regulation of vascular associated smooth muscle cell migration; phagocytosis, engulfment; plasma membrane repair; platelet aggregation; platelet formation; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of endocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of phagocytosis; positive regulation of protein processing in phagocytic vesicle; protein transport; regulated exocytosis; regulation of cell shape; regulation of plasma membrane repair; uropod organization; vesicle targeting
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Reference #:
Q62812
(UniProtKB)
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Alt. Names/Synonyms: Cellular myosin heavy chain, type A; Myh9; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; myosin, heavy polypeptide 9, non-muscle; Myosin-9; NMMHC II-a; NMMHC-A; NMMHC-IIA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; nonmuscle myosin heavy chain-A
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Gene Symbols: Myh9
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Molecular weight:
226,338 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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