MYH9 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  actin cytoskeleton; actin filament; actomyosin; actomyosin contractile ring; apical plasma membrane; brush border; cell cortex; cell leading edge; cell-cell adherens junction; cleavage furrow; cortical cytoskeleton; cytoplasm; cytosol; exocytic vesicle; lamellipodium; lateral plasma membrane; mitochondrion; myosin complex; myosin II complex; myosin II filament; nucleus; plasma membrane; protein-containing complex; ruffle; stress fiber; uropod
Molecular Function:  actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; follicle-stimulating hormone receptor binding; G-protein alpha-subunit binding; identical protein binding; integrin binding; microfilament motor activity; motor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein membrane anchor; scaffold protein binding
Biological Process:  actin cytoskeleton reorganization; actin filament bundle assembly; actin filament bundle distribution; actin filament-based movement; actomyosin structure organization; angiogenesis; blood vessel endothelial cell migration; cell adhesion; cell morphogenesis involved in differentiation; cell-cell adhesion; cellular response to mechanical stimulus; cellular response to platelet-derived growth factor stimulus; cytokinetic process; establishment of meiotic spindle localization; establishment of T cell polarity; follicle-stimulating hormone signaling pathway; in utero embryonic development; meiotic spindle organization; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; negative regulation of actin filament severing; negative regulation of vascular associated smooth muscle cell migration; phagocytosis, engulfment; plasma membrane repair; platelet formation; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of endocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of phagocytosis; positive regulation of protein processing in phagocytic vesicle; protein transport; regulation of cell shape; uropod organization; vesicle targeting
Reference #:  Q62812 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type A; Myh9; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; myosin, heavy polypeptide 9, non-muscle; Myosin-9; NMMHC II-a; NMMHC-A; NMMHC-IIA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; nonmuscle myosin heavy chain-A
Gene Symbols: Myh9
Molecular weight: 226,338 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene