LCAT Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms. Belongs to the AB hydrolase superfamily. Lipase family. Detected in blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Detected in cerebral spinal fluid (at protein level) (PubMed:10222237). Detected in liver (PubMed:3797244, PubMed:3458198). Expressed mainly in brain, liver and testes. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - glycerophospholipid; Secreted; Secreted, signal peptide; Transferase
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  extracellular region; extracellular space; high-density lipoprotein particle
Molecular Function:  apolipoprotein A-I binding; phosphatidylcholine-sterol O-acyltransferase activity; protein binding
Biological Process:  cholesterol esterification; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; high-density lipoprotein particle remodeling; lipoprotein biosynthetic process; phosphatidylcholine biosynthetic process; phosphatidylcholine metabolic process; phospholipid metabolic process; regulation of high-density lipoprotein particle assembly; reverse cholesterol transport; very-low-density lipoprotein particle remodeling
Disease: Fish-eye Disease; Lecithin:cholesterol Acyltransferase Deficiency
Reference #:  P04180 (UniProtKB)
Alt. Names/Synonyms: 1-alkyl-2-acetylglycerophosphocholine esterase; LCAT; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; phosphatidylcholine--sterol O-acyltransferase; Phosphatidylcholine-sterol acyltransferase; Phospholipid-cholesterol acyltransferase; Platelet-activating factor acetylhydrolase; testicular secretory protein Li 24
Gene Symbols: LCAT
Molecular weight: 49,578 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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