LILRB2 Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid-derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 19q13.42
Cellular Component:  cell surface; cytoplasm; extracellular space; ficolin-1-rich granule membrane; membrane; plasma membrane; tertiary granule membrane
Molecular Function:  amyloid-beta binding; cell adhesion molecule binding; inhibitory MHC class I receptor activity; MHC class I protein binding; MHC class Ib protein binding; MHC class Ib protein complex binding; protein binding; protein homodimerization activity; protein phosphatase 1 binding; protein-containing complex binding
Biological Process:  adaptive immune response; cell surface receptor signaling pathway; cell-cell signaling; cellular defense response; cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; Fc receptor mediated inhibitory signaling pathway; heterotypic cell-cell adhesion; immune response; immune response-inhibiting cell surface receptor signaling pathway; interleukin-10-mediated signaling pathway; learning or memory; negative regulation of antigen processing and presentation; negative regulation of calcium ion transport; negative regulation of postsynaptic density organization; negative regulation of protein metabolic process; negative regulation of T cell costimulation; negative regulation of T cell proliferation; positive regulation of interleukin-6 production; positive regulation of long-term synaptic depression; positive regulation of protein dephosphorylation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of dendritic cell differentiation; regulation of long-term synaptic potentiation; signal transduction
Reference #:  Q8N423 (UniProtKB)
Alt. Names/Synonyms: CD85 antigen-like family member D; CD85D; eukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; Ig-like transcript 4; ILT-4; ILT2; ILT4; Immunoglobulin-like transcript 4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; Leukocyte immunoglobulin-like receptor 2; Leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRA6; LILRB2; LIR-2; LIR2; LIRB2; MIR-10; MIR10; Monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10
Gene Symbols: LILRB2
Molecular weight: 65,005 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein