SOS1 Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. Expressed in gingival tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component:  cytoplasm; cytosol; neuronal cell body; nucleosome; plasma membrane; postsynaptic density
Molecular Function:  DNA binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process:  axon guidance; B cell homeostasis; blood vessel morphogenesis; cardiac atrium morphogenesis; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; eyelid development in camera-type eye; Fc-epsilon receptor signaling pathway; G protein-coupled receptor signaling pathway; hair follicle development; heart trabecula morphogenesis; insulin receptor signaling pathway; leukocyte migration; MAPK cascade; midbrain morphogenesis; multicellular organism growth; neurotrophin TRK receptor signaling pathway; pericardium morphogenesis; positive regulation of apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of small GTPase mediated signal transduction; Ras protein signal transduction; regulation of pro-B cell differentiation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of T cell differentiation in thymus; regulation of T cell proliferation; roof of mouth development; signal transduction; vitellogenesis
Disease: Fibromatosis, Gingival, 1; Noonan Syndrome 4
Reference #:  Q07889 (UniProtKB)
Alt. Names/Synonyms: GF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; HGF; NS4; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); SOS-1; SOS1
Gene Symbols: SOS1
Molecular weight: 152,464 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene