WT1 Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. Belongs to the EGR C2H2-type zinc-finger protein family. Expressed in the kidney and a subset of hematopoietic cells. 8 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor
Chromosomal Location of mouse Ortholog: 2 E2-E3|2 55.06 cM
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  C2H2 zinc finger domain binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; double-stranded methylated DNA binding; hemi-methylated DNA-binding; metal ion binding; nucleic acid binding; protein binding; RNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  adrenal cortex formation; adrenal gland development; apoptotic process; branching involved in ureteric bud morphogenesis; camera-type eye development; cardiac muscle cell fate commitment; cellular response to cAMP; cellular response to gonadotropin stimulus; coronary vasculature development; diaphragm development; epithelial cell differentiation; flagellated sperm motility; germ cell development; glomerular basement membrane development; glomerular visceral epithelial cell development; glomerular visceral epithelial cell differentiation; glomerulus development; gonad development; heart development; kidney development; male genitalia development; male gonad development; mesenchymal to epithelial transition; mesonephros development; metanephric comma-shaped body morphogenesis; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; metanephros development; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of female gonad development; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; negative regulation of metanephric glomerular mesangial cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of translation; positive regulation of apoptotic process; positive regulation of DNA methylation; positive regulation of gene expression; positive regulation of heart growth; positive regulation of male gonad development; positive regulation of metanephric ureteric bud development; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; posterior mesonephric tubule development; regulation of animal organ formation; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; RNA splicing; seminiferous tubule development; Sertoli cell development; sex determination; single fertilization; spermatogenesis; thorax and anterior abdomen determination; tissue development; ureteric bud development; vasculogenesis; visceral serous pericardium development
Reference #:  P22561 (UniProtKB)
Alt. Names/Synonyms: D630046I19Rik; OTTMUSP00000015944; RP23-232D1.2; Wilms tumor 1 homolog; Wilms tumor homolog; Wilms tumor protein homolog; Wt-1; Wt1
Gene Symbols: Wt1
Molecular weight: 49,246 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

WT1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene