TEAD4 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6 F3|6 62.92 cM
Cellular Component:  cytoplasm; nucleoplasm; nucleus; protein-DNA complex; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  blastocyst formation; cell fate commitment; cell fate specification; embryo implantation; hippo signaling; in utero embryonic development; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; transcription, DNA-templated; trophectodermal cell fate commitment
Reference #:  Q62296 (UniProtKB)
Alt. Names/Synonyms: ETF-related factor 2; ETF-related factor-2; Etfr; ETFR-; ETFR-2; Etfr2; FGF-regulated 19; FR-19; Rtef; RTEF-1; Rtef1; Tcf13r; Tcf13r1; TEA domain family member 4; TEAD-; TEAD-4; Tead4; Tef; TEF-1-related factor 1; TEF-1-related factor FR-19; TEF-3; Tef3; Tefr; Tefr1; Tefr1a; Transcriptional enhancer factor TEF-3
Gene Symbols: Tead4
Molecular weight: 48,028 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene