PTP-PEST
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) |
Chromosomal Location of human Ortholog: 7q11.23 |
Cellular Component:
cell projection; cytoplasm; cytosol; focal adhesion; nucleoplasm; nucleus; podosome
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Molecular Function:
non-membrane spanning protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding
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Biological Process:
cellular response to epidermal growth factor stimulus; negative regulation of ERBB signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of epidermal growth factor receptor signaling pathway; tissue regeneration
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Disease: Colorectal Cancer
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Reference #:
Q05209
(UniProtKB)
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Alt. Names/Synonyms: protein tyrosine phosphatase non-receptor type 12; protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTP-PEST; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12
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Gene Symbols: PTPN12
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Molecular weight:
88,106 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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