PTP-PEST Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of human Ortholog: 7q11.23
Cellular Component:  cell projection; cytoplasm; cytosol; focal adhesion; nucleoplasm; nucleus; podosome
Molecular Function:  non-membrane spanning protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding
Biological Process:  cellular response to epidermal growth factor stimulus; negative regulation of ERBB signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of epidermal growth factor receptor signaling pathway; tissue regeneration
Disease: Colorectal Cancer
Reference #:  Q05209 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase non-receptor type 12; protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTP-PEST; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12
Gene Symbols: PTPN12
Molecular weight: 88,106 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTP-PEST

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein