NuaK1 a protein kinase of the CAMKL family. Phosphorylated and activated by AKT1 during glucose starvation. May activate ATM kinase under conditions of nutrient starvation. Suppresses apoptosis induced by nutrient starvation and death receptors via inhibition of caspase 8 activation. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; NuaK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  cytoplasm; fibrillar center; microtubule cytoskeleton; nucleus
Molecular Function:  AMP-activated protein kinase activity; ATP binding; histone serine kinase activity; kinase activity; nucleotide binding; p53 binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell adhesion; cellular response to DNA damage stimulus; phosphorylation; protein amino acid phosphorylation; regulation of cell adhesion; regulation of cellular senescence
Reference #:  Q641K5 (UniProtKB)
Alt. Names/Synonyms: AU014801; AW494241; B230104P22Rik; Kiaa0537; MGC90816; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; Nuak1; omphalocele kinase 1; Omphk1; OTTMUSP00000026103; ZNUAK family, SNF1-like kinase, 1
Gene Symbols: Nuak1
Molecular weight: 73,661 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NuaK1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene