NuaK1 Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; NuaK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  cytoplasm; fibrillar center; microtubule cytoskeleton; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; p53 binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell adhesion; cellular response to DNA damage stimulus; intracellular signal transduction; phosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cellular senescence; regulation of myosin-light-chain-phosphatase activity
Reference #:  Q641K5 (UniProtKB)
Alt. Names/Synonyms: AU014801; AW494241; B230104P22Rik; Kiaa0537; MGC90816; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; Nuak1; omphalocele kinase 1; Omphk1; OTTMUSP00000026103; ZNUAK family, SNF1-like kinase, 1
Gene Symbols: Nuak1
Molecular weight: 73,661 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NuaK1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene