SKAP55 Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family. Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component:  cell-cell junction; cytoplasm; cytosol; immunological synapse; microtubule plus-end; nucleus; plasma membrane; plasma membrane raft; ruffle; T cell receptor complex
Molecular Function:  microtubule plus-end binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein-containing complex binding; SH2 domain binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process:  adaptive immune response; cell migration; cellular response to epidermal growth factor stimulus; microtubule cytoskeleton organization; positive regulation of adaptive immune response; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of heterotypic cell-cell adhesion; positive regulation of integrin activation; positive regulation of leukocyte cell-cell adhesion; positive regulation of signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; T cell receptor signaling pathway
Reference #:  Q86WV1 (UniProtKB)
Alt. Names/Synonyms: pp55; SCAP1; SKAP-55; SKAP1; SKAP55; src family associated phosphoprotein 1; Src family-associated phosphoprotein 1; src kinase associated phosphoprotein 1; Src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa
Gene Symbols: SKAP1
Molecular weight: 41,432 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein