SKAP55 Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component:  cell-cell junction; cytoplasm; cytosol; immunological synapse; microtubule plus-end; nucleus; plasma membrane; plasma membrane raft; ruffle; T cell receptor complex
Molecular Function:  microtubule plus-end binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein-containing complex binding; SH2 domain binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process:  adaptive immune response; cell migration; cellular response to epidermal growth factor stimulus; microtubule cytoskeleton organization; positive regulation of adaptive immune response; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of heterotypic cell-cell adhesion; positive regulation of integrin activation; positive regulation of leukocyte cell-cell adhesion; positive regulation of signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; T cell receptor signaling pathway
Reference #:  Q86WV1 (UniProtKB)
Alt. Names/Synonyms: pp55; SCAP1; SKAP-55; SKAP1; SKAP55; src family associated phosphoprotein 1; Src family-associated phosphoprotein 1; src kinase associated phosphoprotein 1; Src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa
Gene Symbols: SKAP1
Molecular weight: 41,432 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein