HIF2A Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2p21
Cellular Component:  cytosol; nuclear speck; nucleoplasm; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; histone acetyltransferase binding; protein binding; protein heterodimerization activity; transcription factor binding
Biological Process:  angiogenesis; blood vessel remodeling; cell maturation; cellular response to hypoxia; embryonic placenta development; erythrocyte differentiation; iron ion homeostasis; lung development; mitochondrion organization; myoblast fate commitment; norepinephrine metabolic process; positive regulation of cold-induced thermogenesis; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein ubiquitination; regulation of heart rate; regulation of transcription from RNA polymerase II promoter in response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia; signal transduction; surfactant homeostasis; transcription by RNA polymerase II; visual perception
Disease: Erythrocytosis, Familial, 4
Reference #:  Q99814 (UniProtKB)
Alt. Names/Synonyms: Basic-helix-loop-helix-PAS protein MOP2; BHLHE73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; EPAS1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2-alpha; HIF2-alpha; HIF2A; HLF; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; MOP2; PAS domain-containing protein 2; PASD2
Gene Symbols: EPAS1
Molecular weight: 96,459 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HIF2A

Protein Structure Not Found.


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