IGF2R Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Vesicle
Chromosomal Location of mouse Ortholog: 17 A1|17 8.64 cM
Cellular Component:  cell surface; clathrin coat; early endosome; endocytic vesicle; endosome; endosome membrane; extracellular space; Golgi apparatus; late endosome; membrane; nuclear envelope lumen; nucleus; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle
Molecular Function:  enzyme binding; G-protein alpha-subunit binding; identical protein binding; insulin-like growth factor binding; insulin-like growth factor II binding; mannose binding; phosphoprotein binding; protein binding; retinoic acid binding; retromer complex binding; signaling receptor activity
Biological Process:  G protein-coupled receptor signaling pathway; liver development; lysosomal transport; positive regulation by host of viral process; positive regulation of apoptotic process; regulation of apoptotic process; response to retinoic acid
Reference #:  Q07113 (UniProtKB)
Alt. Names/Synonyms: 300 kDa mannose 6-phosphate receptor; AI661837; cation-independent mannose 6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; cation-independent MPR; CD222; CI Man-6-P receptor; CI-; CI-MPR; IGF-II receptor; IGF-II/CI-MPR; Igf2r; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P/IG; M6P/IGF2 receptor; M6P/IGF2R; M6PR; mannose-6-phosphate receptor, cation independent; MPR 300; Mpr3; Mpr300; MPRI
Gene Symbols: Igf2r
Molecular weight: 273,815 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene