Kv1.3 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 3 F2.3|3 46.59 cM
Cellular Component:  axon; calyx of Held; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; membrane raft; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; ion channel activity; outward rectifier potassium channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  ion transport; potassium ion export across plasma membrane; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; transmembrane transport
Reference #:  P16390 (UniProtKB)
Alt. Names/Synonyms: Kca1-; Kca1-3; Kcna3; Kv1.; Kv1.3; Mk-3; MK3; potassium voltage gated channel, shaker related subfamily, member 3; Potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3); Voltage-gated potassium channel subunit Kv1.3
Gene Symbols: Kcna3
Molecular weight: 58,564 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene