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Kv1.3
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 3 F2.3|3 46.59 cM |
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Cellular Component:
axon; calyx of Held; glutamatergic synapse; membrane; membrane raft; plasma membrane; postsynaptic membrane; presynaptic membrane; voltage-gated potassium channel complex
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Molecular Function:
delayed rectifier potassium channel activity; monoatomic ion channel activity; outward rectifier potassium channel activity; potassium channel activity; voltage-gated monoatomic ion channel activity; voltage-gated potassium channel activity
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Biological Process:
monoatomic ion transport; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of monoatomic ion transmembrane transport; transmembrane transport
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Reference #:
P16390
(UniProtKB)
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Alt. Names/Synonyms: Kca1-; Kca1-3; Kcna3; Kv1.; Kv1.3; Mk-3; MK3; potassium voltage gated channel, shaker related subfamily, member 3; Potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3); Voltage-gated potassium channel subunit Kv1.3
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Gene Symbols: Kcna3
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Molecular weight:
58,564 Da
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Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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